2 Vasculitis, Causes, Symptoms and How to Overcome

Vasculitis, causes, symptoms and how to overcome. What is Vasculitis ? Vasculitis is a cutaneous or systemic reaction, which is microscopically described as an infiltration of inflammatory cells in the vessel wall, with varying degrees of endothelial cell necrosis and vascular walls. The size of affected blood vessels varies, ranging from large arteries to dermal capillaries and venules. The size of the vessels involved, the infiltrating cell composition. Symptoms of vasculitis depend on the affected primary vessels. In small blood vessels, their manifestations are often palpable purpura, or urticaria, pustules, vesicles, petechiae, or lesions such as erythema multiforme. In medium-sized blood vessels, the clinical manifestations can be ulcers, subcutaneous nodules, livedo reticularis, and digital necrosis.

2 Vasculitis, Causes, Symptoms and How to Overcome
 The most important thing in evaluating patients with vasculitis is recognizing symptoms and signs of systemic disease. Almost all the blood vessels in the skin can get vasculitis; most about venules and called cutaneous vasculitis. Cutaneous vasculitis has histopathological features characterized by neutrophils. infiltration in blood vessels, fibrinoid necrosis, known as leukocytoclastic vasculitis. And granulocyte debris can be found, extravasation of erythrocytes, granulomas or lymphocytic inflammation, and immunoreactant deposition in the vessel wall.

Vasculitis, Causes, Symptoms and How to Overcome

The classification of vasculitis is based on several criteria, including the size of affected blood vessels, clinical manifestations, histopathological features, and causes. Included in the class of large blood vessels are the aorta and large size arteries and veins; medium blood vessels are medium and small size arteries and veins; small blood vessels are arterioles, venules and capillaries.

The most useful classification of vasculitis for clinical applications is an etiological classification, which can be used to distinguish primary and secondary causes. The pathogenesis of immune complexes for vasculitis follows the classic Arthus reaction type. If vasculitis is suspected, several diagnostic steps can be taken to find the cause or rule out the possibility of other processes that can cause secondary vasculitis such as infection, thrombosis and malignancy or can lead to vasculitis-like conditions.

There are several demographic conditions associated with vasculitis, including patient age and race. some types of vasculitis occur in specific populations. In addition, it is necessary to determine which blood vessel organs are affected. The type and extent of the affected organ can help determine the type of vasculitis and initial therapy. Clinical features can be used to see the size of affected blood vessels. History and careful physical examination are needed to support the correct diagnosis. Diagnosis of vasculitis requires histopathological criteria. Two major criteria for histopathological vasculitis, in addition to considering the size of blood vessels involved are endothelial cell damage or vascular wall structure and infiltration of inflammatory cells in the blood vessel wall. Among them the most common are neutrophils, lymphocytes, and nuclear dust. Cells are not always found compared to the two major criteria of vasculitis above, especially in acute lesions, in larger blood vessels, and in granulomatosis vasculitis, damage to the vessel wall is more common due to fibrinoid deposits and fibrinoid necrosis in vessel walls and related structures .

On electron microscopy, these deposits appear as granular, amorphous and fibrillary eosinophils, through immunofluorescence studies, these deposits are known to consist of fibrin composition and antibody antigen complex precipitates. The presence of fibrinoid deposits indicates vascular damage and triggers clots and helps establish a diagnosis of vasculitis. Minor criteria for histopathological vasculitis are based on microscopic examination results. These microscopic examination findings can illustrate the processes that occur in vascular structures, including endothelial edema, continuous bleeding in diseased vessels, thrombosis, epidermal or subepidermal necrosis.

Vasculitis can affect large blood vessels to small blood vessels such as capillaries and venules. Vasculitis can result from chronic disease and can be precipitated by infection. However, most cases are idiopathic. The clinical picture varies according to the affected blood vessels. In addition to histopathological examination, laboratory tests need to be done to help establish the diagnosis, in addition to the history and physical examination.

Signs and Symptoms of Vasculitis

Signs or symptoms of vasculitis depend on what blood vessels and organs are involved in the inflammatory process, and also the severity of the condition of the patient. Some sufferers can have different signs or symptoms. Generally symptoms of vasculitis include:


Numbness or weakness in the hands or feet

Weight loss

Red spots on the skin

Lumps or pain appear on the skin

Not tasty to eat

Shortness of breath and coughing

Sweating at night

Rash appears.


Causes of Vasculitis

Until now it is still unknown what causes vasculitis. Several types of vasculitic disease can be related to genetic factors, while other types of vasculitis can occur due to a disturbance in the immune system that turns against blood vessels. Immune disorders can be influenced by several factors including:

Body reaction to something

Affected by infections such as hepatitis C or hepatitis B

Blood cancer.

Have autoimmune diseases such as lupus, scleroderma or rheumatoid arthritis.
Blood vessels with vasculitic disease will weaken, making it easily inflamed or can also bleed. If the blood vessels become inflamed, the wall will thicken and make the vascular cavity narrow. The risk is the amount of blood that supplies the body's tissues and organs will be reduced.

How to Overcome Vasculitis

In dealing with vasculitis depends on the results of the diagnosis and the affected organs. Vasculitis caused by allergic reactions will generally heal on its own without requiring treatment. Here are some ways to deal with vakulitis at home by changing your lifestyle more healthy:

Set a healthy diet that can prevent problems such as bone loss, high blood pressure, and diabetes. Choose foods that contain lots of high protein such as fruits and vegetables.

Regular exercise, such as walking can prevent high blood pressure, bone loss and diabetes associated with vasculitis. Exercise is also good for the heart and lungs. In addition, many people feel the benefits of exercise to be healthier every day.

However, if vasculitis affects important organs such as the kidneys, lungs and even reaches the brain, then serious medical treatment is needed.

Thus reviews of vasculitis, causes, symptoms and how to overcome. In this paper, the aim is for the reader to get to know more about vasculitis, and thank you for reading.

Artikel Terkait